![]() montana only has DNA damage repair (C19ORF57) (Takemoto et al., 2020) and hypoxia response related to HIF1-α regulation (FUT11, USP8, CASP14, VGLL4, and ALS2) (Troilo et al., 2014 Ye et al., 2018 Rivas et al., 2020 Wang et al., 2020 Ruan et al., 2021). In contrast, PSGs related to altitude adaptation in V. et al., 2018 Hou et al., 2019 Félix et al., 2021), energy metabolism (ARF6 and IRS1) (Dong et al., 2006 Gamara et al., 2021), myocardial growth (EIF3A, IL6ST, SIRT4, and MZB1) (Luo et al., 2016 Klimushina et al., 2019 Miao et al., 2019 Zhang et al., 2021), angiogenesis (IGFBP3, RND3, APLNR, RBPJ, and ARHGEF15) (Lofqvist et al., 2007 Kusuhara et al., 2012 Díaz-Trelles et al., 2016 Mastrella et al., 2019 Wu et al., 2021), and hypoxia stress response (RHEB, WWOX, COMMD1, LAMA4, and PNN) (He et al., 2017 Murata et al., 2017 Hsu et al., 2020 Baryla et al., 2022 Cai et al., 2022). ferrilata, 20 PSGs related to high-altitude environmental selection stress mainly include the following five aspects: DNA damage repair (LIG4, ZNF830, CRTAC1, and GRB2) (Jun et al., 2016 Chen G. ferrilata have more PSGs that may be related to coping with the selection pressure of plateau environment compared with V.
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